Dr. Craig Reese, DC. PC.
3000 Center Green Dr. Suite 230
Boulder, CO 80301

Dr. Reese’s Bits and Pieces
June 2017 Newsletter

Hard to believe I’m writing the June newsletter as the snow is piling up outside!  Good old Colorado weather…

Endocrine System Part 3
The last two months (April and May newsletters are posted on the website) I’ve been talking about the endocrine system and the main concerns that must be addressed to help balance someone’s hormones:
There are 4 main areas that must be addressed to balance someone’s endocrine system:

  1. Support and stabilize blood glucose.
  2. Balance essential fatty acids (Omega 3 & 6)
  3. Support liver biotransformation (the ability to detox the chemicals and poisons in our environment)
  4. Normalize gut function and flora. (infections, good bacteria, more fermented foods, clean diet, etc.)

I covered in detail blood sugar imbalance and insulin surges plus the problems they cause.

Essential Fatty Acids

Many of us grew up in a fat-phobic world were all fats were bad.  It’s true that trans fats are bad but in moderation the rest of the fats are good.  Essential means that they must be in your diet since your body can’t make them.  Omega 3 and 6 are the essential fatty acids that you need to eat or supplement to stay healthy and to produce prostaglandins which are necessary for proper hormone signaling.  Prostaglandins affect multiple hormone synthesis and secretion pathways in the hypothalamus-pituitary axis as well as ovulation, implantation and menstruation.  Omega 3 are vital for fertility problems.

Omega 6 can produce prostaglandin 1 (PG-1) and 2 (PG-2) while omega-3 produces PG-3.  PG-1 and 3 are anti-inflammatory and prevent clotting.  PG-2 creates inflammation, swelling and clotting. A balance between PG-1,3 and PG-2 is vital for healthy function and ideal hormone signaling.  Increased consumption of omega 6 fatty acids in the diet from fried foods and vegetable oils, shifts the away from PG-1 into PG-2 production.

The Standard American Diet (SAD) is high in omega-6 and low in omega-3 creating a shift into inflammatory prostaglandin production.  Excess sugar, trans fats, insulin surges, inflammation, protein deficiencies, hypothyroid and alcohol consumption can affect which PG’s are made.  Finally, a deficiency in vitamins B3, B6, magnesium, zinc and molybdenum can affect PG production.  Natural hormone replacement is not going to fix a fatty acid imbalance or insulin surges.

Normalize Gut Function and Flora

Here are some key points about the human body's microbial population:

  1. The human microbiota is made up of trillions of cells - including bacteria, viruses and funguses - and they outnumber our own cells tenfold.
  2. The biggest populations of microbe reside in our gut - the gut microbiota. Other habitats include the skin.
  3. The microbial cells - and their genetic material, the microbiome - live with us in an innate relationship that is vital to normal health, although some species are also opportunistic pathogens that can invade us and cause disease.
  4. The microorganisms living inside the gastrointestinal tract - also known as the gut flora - amount to as much as 4 pounds of biomass, with every individual having a unique mix of species.
  5. The microbiota is important in nutrition, immunity and effects on the brain and behavior. It is implicated in numerous diseases when the normal individual balance of microbes is disturbed.


Dysbiosis is and over-growth of abnormal microbes such as certain bacteria, yeast, parasites, etc., that do not have a beneficial role in microbiota.  One of the best sources of good bacteria is to eat fermented foods.  Vinegar, olives, pickles, sauerkraut, kim chi, etc.  I am not a fan of kombucha since it rarely tests well on patients.

Microbiome dysbiosis disrupts intestinal breakdown of hormones and reduces hormonal clearance and causes hormone dysregulation. It also reduces the metabolic effect from natural supplements.

Leaky gut is a breakdown of the intestinal barrier that allows large proteins, microbes and toxins to sneak into the systemic circulation.  It is caused by numerous factors:

  1. Diet-alcohol, gluten casein, processed foods, excess sugar and fast food.
  2. Medications- steroids, antibiotics, antacids, xenobiotics (Examples of Xenobiotics are compounds that include drugs, food additives, and environmental pollutants)
  3. Infections-H. pylori, bacterial overgrowth, yeast overgrowth, intestinal virus, parasitic infections.
  4. Stress-increased or decreased cortisol, increased catecholamines (adrenaline and dopamine).
  5. Hormonal-decreased thyroid, progesterone, estradiol, or testosterone inhibits re-lining of the gut.
  6. Neurologic-brain trauma, stroke, neurodegeneration.
  7. Metabolic-glycated end products, intestinal inflammation, autoimmune conditions.

You can see why leaky gut is so prevalent and needs to be treated before you can be healthy.

With a leaky gut, Lipopolysaccharides (LPS) slips through the breaks in the intestinal barrier and into the blood. 
This creates dysregulation of the hypothamic-pituitary axis which alters estrogen, testosterone and progesterone feedback. 

LPS alters cortisol responses and creates adrenal fatigue.  LPS creates systemic inflammation which promotes insulin resistance, downregulation of hormone enzyme pathways and promotes hormone shifts.

It is vital to fix your gut, ingest good bacteria, get rid of your infections, clean up your bad diet and take your Omega 3’s if you ever want to have a normal endocrine system.